fibre7orange
Messages : 612
Date d'inscription : 22/01/2013
 |  Sujet: The molecular dynamics simulations have provided insight  Lun 5 Fév - 6:26 | |
| In silico introduction of the double mutation D1-A209S/D1- C212S to the resolved structure of T. elongatus provides insight into the structural and energetic differences between PSIIRC of wild-type Synechocystis sp. PCC 6803 and the AC mutant. Hereafter, we will refer to the structure of PSIIRC from T. elongatus as representing the putative structure of the AC, and the one obtained by in silico CP-690550 JAK inhibitor D1-A209S/D1-C212S double mutation, as representing the structure of DKS. PCC 6803. The molecular dynamics simulations have provided insight into the interaction potential of the D helices of the D1 and D2 proteins. An additional hydrogen bond was observed between D1-Ser209Oc and D2-Ile204O. As a result of this change in the inter-helical hydrogen bond network, Tubulin Acetylation Inducer HDAC inhibitor the D helices of the modeled mesophilic D1 and D2 proteins take on a conformation that is different from the thermophilic one. Thus, to form the new H-bond there is a need for a more relaxed environment. It is well known that the photosynthetic membrane lipids present increased saturation with increasing temperature in different strains of cyanobacteria and higher organisms. | |
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