At the end of the experiments, rats were sacrificed by cardiac puncture under anesthesia

Salvianolic acid B, the aqueous bioactive component from Salvia miltiorrhiza Bunge, is a polyphenolic compound found in abundance in this plant. The structure of Sal B is shown BAY-60-7550 PDE inhibitor
in Figure 1 which consists of three molecules of Tanshinol, or called danshensu b-3,4- dihydroxyphenyl lactic acid and a molecule of caffeic acid, Sal B can be converted in vivo to Tanshinol, another water-soluble bioactive ingredient of Salvia miltiorrhiza Bunge, with similar function to Sal B. Both Sal B and Tanshinol BEZ235 PI3K inhibitor are wellknown as among the most effective natural product antioxidants. Multiple pharmacological studies have found that Sal B can attenuate the effect of myocardial ischemia-reperfusion injury. Interestingly, Sal B can also increase angiogenesis and reduce myocardial ischemia via vascular endothelial growth factor activation.