the serum bone biomarkers alkaline phosphatase and tartrate-resistant acid

Therefore, we hypothesize that the clinical use of Sal B will hold promise for Bortezomib Proteasome inhibitor a more effective and safe treatment for GIO. The aim of the current study is to validate our hypothesis in a GIO rat model and additional study on in vitro. The original herbal medicine Radix Salviae miltiorrhiza was selected BMN673 PARP inhibitor
according to the standard protocol of the pharmacopoeia of the People’s Republic of China. The aqueous bioactive component from Radix Salviae miltiorrhizae was extracted as previously reported. Salvianolic acid B and Tanshinol found in the aqueous extract of Radix Salviae miltiorrhizae were characterized by HPLC using a standard reference from the Chinese Biological Appraisal Institute, Beijing, China. HPLC chromatograms of the control compounds and aqueous extraction samples are shown in Figure 2. The content of Sal B was 25 mg per gram of Radix Salviae miltiorrhiza.